We will see Thor after a long time in any Marvel Movie or series so the story will after just after Thor leaves Earth and New Asgard with the Guardians of the Galaxy
As he can be seen gaiting trained as the look in the trailer is just like the look of Thor in the Avengers: Endgame, He must be looking for a training place for himself now.
Thor: Love and Thunder has shown various planets and cultures of the UNiverse and hence the films will be a Space Odessy, where team will fight with many villains
Norse mythology would also play a pivotal role in the movie as we can see the statue of Hercules in the Trailer and we can see Thor and team under the statue.
Mighty Thor: Jane Foster has somehow become the Mighty Thor and she is worthy of lifting the mjolnir, it would be interesting to watch the story behind the incident