At CinemaCon, Marvel Studios hinted that Deadpool & Wolverine's story happens before Loki's series in the MCU. Deadpool's mission is to guard the Sacred Timeline, wrecked in Loki season 1 and swapped with Loki's new Yggdrasil in season 2.
Despite alterations to their origin story in their debut in 2015's "Avengers: Age of Ultron," Wanda and Pietro Maximoff, also known as Scarlet Witch and Quicksilver, could seamlessly fit into Deadpool and Wolverine's mutant-centric storyline.
Throughout much of the MCU's history, Samuel L. Jackson's portrayal of Nick Fury has served as a central figure, connecting numerous superheroes within the franchise.
Doctor Strange is super important in the Multiverse Saga of the MCU. He knows a lot about different universes, so he's a key player. It would be awesome to see him team up with Deadpool and Wolverine.
In 2025, Wilson will be back in "Captain America: Brave New World," and he might be a big part of future MCU stuff. Deadpool and Captain America teamed up a lot in the comics, but now Sam Wilson might fill in for Captain America in the movies.
Thanos, played by Josh Brolin, was the big bad in the Infinity Saga of the MCU. But in "Avengers: Endgame," it looked like his story ended. However, Brolin hinted that Thanos might come back to the MCU. We're not sure where, but maybe in Deadpool and Wolverine's adventure.
She-Hulk is a lawyer and superhero, played by Tatiana Maslany. She has a cool connection to Deadpool because she can break the fourth wall, like in the comics. Deadpool learned this trick from her.
Oscar Isaac played Moon Knight for the first time in his own TV show in Phase 4. Moon Knight is tough like Deadpool, so it would be cool to see them team up in Deadpool & Wolverine.
After the last Spider-Man movie, Peter Parker is all by himself in the MCU, keeping his superhero identity a secret. He'll need new friends for his future adventures, and teaming up with Deadpool could be perfect.
We haven't seen Mark Ruffalo's Hulk in the MCU since She-Hulk's show. It's been a while, and Deadpool & Wolverine could be the perfect movie for him to come back.